A new study reveals amyloid beta, known for its connection to Alzheimer’s, may boost the immune response against cancer by protecting T-cell energy production.
October 11, 2025
Source:
New Atlas
Breakthrough in Alzheimer’s and Cancer Science
Scientists have identified amyloid beta (Aβ), long known for its role in Alzheimer’s disease, as a potential ally in the fight against cancer. New data shows Aβ can enhance the body’s immune response by protecting T-cells, key agents in targeting cancer cells (Nature).
Dual Function of Amyloid Beta
Central nervous system: In Alzheimer’s, Aβ accumulates in the brain, causing damage and memory loss (National Institute on Aging).
Immune system: In T-cells, Aβ surprisingly protects mitochondria (the cell’s energy source) by blocking ceramide, a lipid causing cellular aging (National Cancer Institute).
This dual role may explain why Alzheimer’s patients tend to develop cancer less often, a phenomenon called inverse comorbidity.
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Source:
SciTechDaily
Mechanisms That Boost Immunity
Amyloid Beta Preserves T-Cell Power
Mitochondria: Amyloid beta stops ceramide from damaging T-cell mitochondria, keeping these immune cells energetic and effective.
Fumarate Metabolism: The protein also helps maintain fumarate levels, essential for metabolic health in aging T-cells (Nature).
Mouse Study Insights
T-cells from Alzheimer’s-model mice showed superior cancer-fighting ability in lab tests and when transferred into other mice, slowed tumor growth noticeably (National Cancer Institute).
Therapeutic Potential
Directly increasing Aβ is not safe due to its neurotoxic effects. However, targeting the ceramide and fumarate pathways could replicate the immune benefits without harming the brain.
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Source:
http://Bioengineer.org
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