How the Molecule Attacks Cancer

The newly discovered molecule, 2-MiCit, launches a two-pronged attack on cancer cells, making them more vulnerable to treatment.

Mechanism of Action

• Metabolic Disruption: 2-MiCit targets the mitochondria, the powerhouses of the cell. It inhibits a key enzyme, disrupting the cell's metabolism and energy production.

• DNA Damage: This metabolic stress leads to significant damage to the cancer cell's DNA, further weakening it.

This dual attack creates a powerful synergy with the widely used chemotherapy drug 5-fluorouracil (5-FU). When combined, the likelihood of cancer cell death increases substantially compared to using chemotherapy alone.

Preclinical Validation

The anti-cancer effects were rigorously tested across multiple models:

1. C. elegans worms and fruit flies: Showed increased survival rates and chemotherapy sensitivity.

2. Human cancer cells: Confirmed the potent cell-killing effects in a lab setting.

These successful tests underscore the molecule's potential as a future therapeutic agent.