A University of Basel study finds that double-stranded RNAs from nematodes' diets trigger mild stress defenses, boosting cellular health and longevity. Results could inform new strategies for healthy aging in humans, though current evidence is limited to worms.

October 15, 2025

Source:
Science Daily
Diet Induces Cellular Defense in Worms
Scientists at the University of Basel have found that specific nutrients in a worm's diet activate stress response defenses that may slow the aging process. The team studied the microscopic worm Caenorhabditis elegans, showing dietary double-stranded RNAs from bacterial food stimulate protective mechanisms against protein damage, a process closely linked to aging (ScienceDaily).
How the Stress Response Works
Double-stranded RNAs from bacteria are absorbed in the worm’s gut.
These RNAs trigger a mild, beneficial stress response.
The response activates autophagy, a process that removes damaged proteins and helps prevent toxic buildup associated with neurodegeneration.
This effect is systemic, influencing organs throughout the body, not just the gut.
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Source:
SciTechDaily
Results Show Improved Health and Longevity
Worms fed with bacterial diets rich in double-stranded RNAs outperformed their peers. The treated nematodes enjoyed greater activity, improved cellular health, and extended lifespan compared to control groups (University of Basel).
Broader Implications for Human Aging
While this research is currently restricted to nematodes, its findings support the idea that hormetic dietary stress—mild stress from food—might activate similar anti-aging pathways in higher animals, including people. Related studies on caloric restriction and plant-based compounds suggest similar principles in mammals, though mechanisms may differ.
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Source:
SciTechDaily
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