Wake Forest University research finds that residents of socioeconomically disadvantaged neighborhoods face higher biological risks of Alzheimer's and vascular brain disease, especially among Black Americans. Addressing social and environmental factors like housing, education, and community resources could be vital in reducing dementia risk.
October 31, 2025
Source:
SciTechDaily
Neighborhood Factors Raise Dementia Risk
New findings from Wake Forest University show that people living in disadvantaged ZIP Codes face heightened biological signs of Alzheimer’s and vascular brain disease. Social and economic stressors in neighborhoods—such as poor housing, limited education, and low income—are associated with a greater risk of dementia, particularly for Black residents.
Research Details
Scientists analyzed data from 679 adults in the Healthy Brain Study.
The study found evidence of increased Alzheimer’s and vascular brain disease markers in high-burden neighborhoods.
Black participants faced more pronounced risks, highlighting ongoing disparities due to structural racism.
This research supports earlier findings that worse neighborhood resources mean higher blood pressure and poorer cognitive performance, even for those without memory problems (ScienceDaily).
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Source:
Neuroscience News
Social Determinants and Brain Health
Social determinants of health—including quality of housing, educational opportunities, and income stability—directly affect dementia risk. Limited resources can result in chronic stress, reduced access to healthcare, and fewer opportunities for cognitive engagement. According to researchers, these factors produce changes in the brain that raise the likelihood of developing dementia (Wake Forest News).
Shifting The Narrative
The study urges a move away from purely genetic or biological explanations for dementia.
Community-level interventions may help protect brain health on a larger scale.
Improving neighborhoods may lower dementia rates more effectively than individual medical treatment alone (Alzheimer’s Association).
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Source:
Medical Xpress
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