Novo Nordisk acquires Akero Therapeutics in a $4.7 billion deal, strengthening its position in the expanding MASH market and planning new treatment synergies.
October 9, 2025
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Novo Nordisk
Deal Value and Strategic Direction
Novo Nordisk has reached a definitive agreement to acquire Akero Therapeutics for an upfront payment of $4.7 billion, with additional milestone payments that could raise the total value to $5.2 billion (company press release). Shareholders will receive $54 per share in cash and up to $6 more per share if Akero’s leading drug candidate, efruxifermin (EFX), secures full US regulatory approval for compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis (MASH).
MASH Market Outlook
MASH, formerly called NASH, is a progressive liver disease closely linked to obesity and metabolic dysfunction. It's projected to impact up to 122 million US adults by 2050 (The Scientist).
The acquisition positions Novo Nordisk as a central player in MASH treatment, a field experiencing significant investment and competition.
Major competitors include Roche, which recently acquired 89bio for its FGF21 analog (Endpoints News).
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Source:
Akero Therapeutics
Pipeline Integration and Clinical Progress
Efruxifermin's Promise
Akero’s efruxifermin (EFX) stands out for its clinical results. The drug is currently in Phase 3 trials for moderate to advanced liver fibrosis and compensated cirrhosis linked to MASH. Notably, EFX demonstrated significant fibrosis regression in Phase 2 studies, including rare improvement in compensated cirrhosis patients (Akero press release).
Phase 2 data: 49% reduction in precirrhotic MASH, 29% in compensated cirrhosis (vs. 19% and 11% for placebo).
EFX is the only agent so far to show significant histological improvement in this advanced group.
Portfolio Synergy
Novo Nordisk plans to integrate EFX with its established metabolic disease drugs, such as semaglutide (Wegovy), which recently received FDA approval for MASH (FDA). Combination and sequencing approaches are actively being explored as potential next standards in metabolic liver disease therapy.
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