A new study reveals that DMT, a natural psychoactive compound, can significantly reduce stroke-induced brain damage by restoring the blood-brain barrier and curbing inflammation.
October 7, 2025
Source:
Nature
A Psychedelic's Healing Potential
Scientists have uncovered a promising new role for a well-known psychedelic compound in brain recovery following a stroke. A recent study published in Science Advances reveals that DMT (Dimethyltryptamine) can significantly reduce brain damage in both animal and cell models.
The research, conducted by a team from the HUN-REN BRC Institute of Biophysics and Semmelweis University, highlights two key benefits.
Key Discoveries
Barrier Restoration: DMT was found to help repair the blood-brain barrier, a critical defense mechanism for the brain.
Inflammation Control: The compound effectively reduces neuroinflammation, a major cause of secondary damage after a stroke.
These findings suggest DMT could become a vital tool in improving outcomes for stroke survivors.
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Source:
http://ScienceDirect.com
How DMT Protects the Brain
The therapeutic effects of DMT appear to stem from a dual-action mechanism that addresses stroke damage on multiple fronts.
Restoring a Critical Shield
A stroke can compromise the blood-brain barrier (BBB), leaving the brain vulnerable. The study found that DMT acts on Sigma-1 receptors to support the astroglial cells responsible for maintaining the BBB's structure and function. This helps restore the protective shield around the brain.
Calming Inflammation
Brain swelling and inflammation are common and dangerous consequences of a stroke. DMT was shown to inhibit the production of proinflammatory cytokines and limit the activation of microglia, the brain's primary immune cells. This targeted anti-inflammatory action helps prevent further neuronal damage.
"DMT acts through Sigma-1 receptors to limit microglial activation and support astroglial cells, creating a dual protective effect," one of the researchers noted.
Read More
Source:
Frontiers
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